Adaptive Biotechnologies, based in Seattle, WA, is a pioneer and leader in immune-driven medicine that aims to improve people’s lives by learning from the wisdom of their adaptive immune systems. Adaptive’s Immune Medicine Platform reveals and translates insights from the human adaptive immune systems with unprecedented scale and precision. Working with drug developers, clinicians, and academic researchers, Adaptive is applying these insights to develop products that will transform diseases such as cancer, autoimmune conditions, and infectious diseases.
For a rapidly growing company like Adaptive Biotechnologies, maintaining and improving critical software systems are top priorities.
Custom Software Powers Modern Laboratories
Adaptive has developed a comprehensive suite of custom software solutions to support their complex laboratory business. Their software team is also responsible for an implementation of Clarity LIMS, an off-the-shelf system that manages wet lab workflows. Adaptive has a mature software development organization with an advanced Agile practice suitable for their feature release and compliance milestone cadence. They must ensure that all software instances, whether fully custom or COTS, are validated according to various regulatory environments including CAP, CLIA, and the FDA. Adaptive requires a team of experienced and qualified developers capable of executing the software engineering roadmap of a complex NGS laboratory.
Maintaining the Right Sized Technical Team
Adaptive requires individuals with experience in regulated software development environments. This includes software team members that not only have strong programming experience, but also can adopt established process and integrate with a fast-paced team. New business goals and new regulatory requirements can sometimes lead to an urgent need for technical resources to work on the critical software systems.
Scaling the Diagnostic Business
Increased sample throughput requires software that evolves to support higher laboratory efficiency. This results in a new test development pipeline to include assays with complex software needs. New tests also increase the load of regulatory compliance activities that must be supported by software systems.
During times of growth, laboratory businesses need a trusted partner that provides domain-specific software staffing solutions appropriate to their goals. Adaptive’s engagement with Semaphore includes a specialized solution for their growing business.
Expert Laboratory Software Staffing: Semaphore’s full-stack software engineers, experienced in the NGS clinical diagnostic domain, are high contributors on Adaptive’s internal software team.
Pool of Experts: Adaptive benefits from Semaphore’s collective knowledge of NGS clinical diagnostic laboratories and custom software solutions. When complex challenges arise, Adaptive technical staff are able to draw upon Semaphore’s pool of software experts to provide additional software architecture and laboratory workflow consulting as needed.
Software Development Practices: Semaphore’s technical team is committed to software engineering practices that lead to high-quality software. Our experienced developers fully participate in Adaptive’s well-established software methodology and quality practice.
Quick Ramp Up: Semaphore’s team members quickly and efficiently integrate into Adaptive’s software organization due to Semaphore’s extensive experience developing software for clinical diagnostic laboratories.
Flexible Staffing Arrangements: Successfully managing the software systems for a dynamic laboratory business requires a partner that can respond to an evolving development plan. Semaphore continually works with Adaptive management to help meet business goals in a fast-changing landscape.
Adaptive Biotechnologies celebrated multiple successes in 2018-2019, including the FDA De Novo designation for their clonoSEQ Assay which detects and monitors minimal residual disease (MRD) in patients with multiple myeloma (MM) and B-cell acute lymphoblastic leukemia (ALL) using DNA from a patient’s bone marrow sample. Furthermore, Adaptive also received Medicare coverage for the clonoSEQ Assay, which supports their work to obtain coverage for eligible patients in need.
Adaptive was able to meet software development milestones during a time of increased load due to FDA clearance, and continues to scale laboratory infrastructure to meet the demands of innovative new test development and increased in sample throughput.
With the support of Semaphore’s expert software staff solutions, Adaptive is able to navigate the clinical diagnostics market with minimal risk due to variable demand in their software roadmap.
Laboratory System Integration
We integrate laboratory information management systems (LIMS), laboratory information systems (LIS), order and results systems, requisition provisioning, Enterprise Resource Planning (ERP), Customer Relationship Management (CRM), project management and custom portals. No matter your workflow, we make it happen.
Analysis Pipeline Integration
We support your analysis solution. Our software professionals provide efficient solutions for ensuring sequencing data securely enters your analysis platform of choice, and final reports are delivered to the right place.
Automating the exchange of setup information and result data with instruments increases laboratory efficiency and accuracy. We have experience integrating the full range of molecular diagnostic instruments, from QC instruments to sequencers to automated liquid handlers.
Electronic Medical Record (EMR) Systems Integration
EMR integration ensures that critical test and patient information enters the laboratory efficiently and error-free, and results are communicated accurately and quickly. Whether using EPIC, Cerner or another EMR system, we can integrate your laboratory systems via HL7.
Increasing sample throughput requires significant automation of laboratory processes and information management. Our team builds and maintains some of the highest throughput NGS labs in the world and can apply that experience to help you achieve your throughput goals.
In addition to tracking physical samples, clinical diagnostic laboratories need to efficiently manage the orders that accompany samples. From the physician portal to the dashboard that manages order status, our customized system ensures that your lab’s orders are processed efficiently and accurately.
We build custom solutions that support business process related to the laboratory workflow including Order and Result Portals, HIPAA Compliant Databases, Panel Selection Websites, Project Management Dashboards. If you can’t find off-the-shelf solutions, talk to us about how we efficiently build solutions that exactly match your requirements.
Software Engineering Services
We understand that laboratory software needs change over time. Let us support your team with a single developer or full team.